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Description
| Application | Non-gelling λ-carrageenan is used to induce inflammation and inflammatory pain in the rodent hindpaw or air pouch models. More recently carrageenan has been injected directly into the joints of rodents to model arthritic pain and inflammation. |
| General description | Carrageenans are mucopolysaccharides from the cell walls of the red algae. They are anionic linear polymers composed of 1,3α-1,4β-galactans having one (κ-), two (ι-) or three (λ-) sulfates per disaccharide unit. In ionic solutions, κ- and ι-carrageenans self-associate into helical structures that form rigid or flexible gels, respectively. λ-carrageenans do not form helices and are non-gelling. Carrageenans are used commercially as thickeners and stabilizing agents. |
| Preparation Note | This product is isolated from two species, Gigartina aciculaire and G. pistillata, which grow together in the sea. |
Properties
| type | Type IV |
| solubility | H2O: 10 mg/mL |
Safety
| WGK Germany | 2 |
| RTECS | FI0704000 |
References
| reference | Peter-Szabo, M., et al., Quantitative characterization of a repeated acute joint inflammation model in rats. Clin. Exp. Pharmacol. Physiol. 34, 520-526, (2007) Abstract |
| | Gabriel, A.F., et al., The CatWalk method: a detailed analysis of behavioral changes after acute inflammatory pain in the rat. J. Neurosci. Methods 163, 9-16, (2007) Abstract |
| | Sedgwick, A.D., and Lees, P., A comparison of air pouch, sponge and pleurisy models of acute carrageenan inflammation in the rat. Agents and Actions 18, 439-446, (1986) |
| | Morris, C.J., Carrageenan-induced paw edema in the rat and mouse. Methods Mol. Biol., (2003) 225, 115-121 |
| | Michel, G., et al., Bioconversion of red seaweed galactans: a focus on bacterial agarases and carrageenases. Appl. Microbiol. Biotechnol. 71, 23-33, (2006) |
